Learn about pfic

Progressive Familial Intrahepatic Cholestasis (PFIC) is a general term that represents a group of rare genetic (inherited) disorders that cause a progressive (increasingly severe) liver disease and can lead to cirrhosis and end-stage liver disease. Often the hallmark feature of this disorder is severe and debilitating pruritus (itching).

“PFIC” is an umbrella term to refer to different types of familial intrahepatic cholestatic diseases. Read on to learn more about all PFIC related diseases.

The Basics

Understand what constitutes liver disease, what is bile and bile acid and finally learn the signs of cholestasis in children.

The Itch

Cholestatic pruritus, also known as itching, is one of the defining symptoms of cholestasis in many patients.

Types And Subtypes

The 6+ different subtypes of PFIC involve mutations of different genes and proteins.

Diagnosis

Diagnostic tests are used to identify PFIC and potentially determine which type of PFIC is present.

Treatment

There are different treatments which depend on the severity, subtype of PFIC and the type(s) of symptoms.

The Genetics

Basic overview of genetics and a closer look at the genetics of PFIC by subtype.

Educational Brochures

A resource that was created to help understand the PFIC diagnosis and terminology.

Educational Webinars

View a series of educational webinars to better understand the PFIC diagnosis and treatment options.