Learn about PFIC


What is PFIC?

Progressive Familial Intrahepatic Cholestasis (PFIC) is a general term that represents a group of rare genetic (inherited) disorders that cause a progressive (increasingly severe) liver disease and can lead to cirrhosis and end-stage liver disease. There are over 6 different types of PFIC. While the different types of PFIC have overlapping symptoms, each one is unique and can differ in disease presentation and prognosis. Often the hallmark feature of this disorder is severe and debilitating pruritus (itching). The disease typically presents in infancy or early childhood. The exact prevalence is unknown, but PFIC is estimated to affect 1 in 50,000-100,000 people worldwide. There is currently no cure for PFIC and related diseases.

Click on the topics below to learn about PFIC, including diagnosis, genetics and possible treatments.

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Want to dive deeper into the science and research around PFIC? Check out our Science and Research page or read articles from our PFIC Research Library. The Research Library contains scientific articles about PFIC and related diseases that have been summarized by a committee of experts and reviewed by our Medical Advisory Board.